images4.jpgAs my comment awaits moderation I figure I better post it here in case I forget.  How about this one?  Okay, I don’t claim to know it all, but the minute I saw mice as the subjects, I immediately had to say something.  

Here’s an excerpt from the article:   

“Even when the mice are not active, turning on the chemical switch activates the same fat-burning process that occurs during exercise. The resulting shift in energy balance (calories in, calories burned) makes the mice resistant to weight gain on a high fat diet”.

The only problem with this exercise pill is mice have brown adipose (fat) tissue. Humans have a white or yellowish which stores reserve energy.

Everyone is familiar with white adipose or fat tissue, which provides insulation and, by storing triglyceride, serves as an energy depot. Many mammals also have brown adipose tissue, which also stores triglyceride, but has the unique ability to generate heat.

Brown adipose tissue is sometimes mistaken for a type of gland, which it resembles more than white adipose tissue. It varies in color from dark red to tan, reflecting lipid content. Its lipid reserves are depleted when the animal is exposed to a cold environment, and the color darkens. In contrast to white fat, brown fat is richly vascularized and has numerous unmyelinated nerves which provide sympathetic stimulation to the adipocytes.

Brown fat is most prominent in newborn animals. In human infants it comprises up to 5% of body weight, then diminishes with age to virtually disappear by adulthood.

A good place to observe brown fat is in mice, where it persists into adulthood. Dissection of a mouse will reveal two large, lobulated masses of brown fat on the dorsal aspect of the thorax, between the scapulae. Masses of brown fat are also to be found around the aorta and in the hilus of the kidney.

Examination of sections of white and brown fat at low magnification reveal dramatic differences in structure, as seen below in images of mouse tissues.

White adipocytes (right panel) have a scant ring of cytoplasm surrounding a single large lipid droplet. Their nuclei are flattened and eccentric within the cell.
Brown adipocytes (left panel) are polygonal in shape, have a considerable volume of cytoplasm and contain multiple lipid droplets of varying size. Their nuclei are round and almost centrally located.
Brown fat is of particular importance in neonates, small mammals in cold environments, and animals that hibernate, because it has the ability to dissipate stored energy as heat. 

Fat is an energy source for humans.  We burn energy, not heat(brown adipose). 

Classic example of the media selling stories. 99.9% of people reading this have no clue that human fat cells and mice fat cells have a DISTINCT difference.